Coded-Mask Prompt Gamma Imaging for Proton Range Verification with Pure Cherenkov Crystal Detectors
by
IFAE Seminar Room
In-person
Accurate proton range verification (PRV) in proton therapy (PT) remains an unmet clinical need, and is essential to fully exploit the potential of PT to improve treatment effectiveness and reduce side effects. We present a computer simulation study (using GATE 10) of an imaging system based on Cherenkov light detection, combining an array of PbF2 crystal detectors with a coded-aperture mask for real-time PRV. In this seminar, I will explain the general process of image reconstruction using iterative algorithms, along with their limitations and computational demands, and how they apply to this system to reconstruct the point at which the proton beam stops (known as the distal fall-off position). Under realistic proton beam conditions, this reconstruction achieved good accuracy and precision for sufficiently high beam intensities. This work presents the concept and demonstrates the feasibility of using Cherenkov-based coded-aperture imaging for proton range verification, through a simulation framework.
Dorian Amaral, Elia Bertoldo, Tomas Kvietkauskas, Clarisse Prat, Francesco Sciotti